Authors
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David Weinstein, MD, on Delivering Gene Therapy Directly to the BrainThe senior vice president of clinical development at Passage Bio discussed intracisternal magna administration of PBGM01.
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Frank Borriello, MD, PhD, on Next Steps for SUPLEXA-101 for Solid TumorsThe scientific cofounder and chief executive officer of Alloplex Biotherapeutics discussed progress of the phase 1 trial and possible future evaluations of the therapy.
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Marty Giedlin, PhD, on Advantages of Allogeneic NK Cell Therapy ApproachesThe senior vice president of Technical Operations at Senti Biosciences discussed the company’s NK cell logic-gating platform and allogeneic approach.
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Unraveling the Genetics of GlaucomaDetails enhance knowledge of biological pathways that contribute to disease pathogenesis.
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Unraveling the Genetics of GlaucomaDetails enhance knowledge of biological pathways that contribute to disease pathogenesis.
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Dr. Hwu on the Uptake of Cellular Therapy in OncologyPatrick Hwu, MD, discusses the uptake of cellular therapy in the treatment of patients with cancer.
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Binod Dhakal, MD, on Benefit of Cilta-Cel in Earlier Lines of Multiple Myeloma TreatmentThe associate professor at Medical College of Wisconsin discussed current studies evaluating cilta-cel and ongoing research.
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Stem Cell Therapy for TBI: Masahito Kawabori, MD, PhDThe associate professor at Hokkaido University and investigator of STEMTRA also discussed other efforts in stroke, Alzheimer disease, and Parkinson disease.
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Gene Transfer Therapy Requires Further Investigation Despite Potential Approval, Review SaysAfter a more than 35-year pursuit, the licensing of a gene therapy product for treating hemophilia may be available within 2 years.
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Dr. Hutson on Challenges With Targeted Therapy in Non-Clear Cell RCCThomas Hutson, DO, PharmD, discusses challenges with targeted therapy in non-clear cell renal cell carcinoma.
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The Potential of Gene Transfer Therapy in SMAJohn Brandsema, MD, discusses gene transfer for the management of SMA and the recent approval of onasemnogene abeparvovec-xioi.
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Dr. Till on the Potential to Utilize CAR T-Cell Therapy Earlier in MCLBrian Till, MD, discusses the potential to utilize CAR T-cell therapy earlier in the treatment of patients with mantle cell lymphoma.
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Cilta-Cel Demonstrates Durable Responses at 18 Months in Relapsed/Refractory Multiple MyelomaCiltacabtagene autoleucel, an investigational BCMA-directed CAR-T therapy, sustained efficacy and durable responses in heavily pretreated patients with relapsed/refractory multiple myeloma.
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The Role of CAR NK Cells: Competition or Compliment to CAR T-Cell Therapy?New studies into chimeric antigen receptor (CAR)–engineered natural killer (NK) cells has shown promising results, explained Ulrike Köhl, PhD, MD, professor of immune oncology and director of the Institute for Clinical Immunology at the University of Leipzig in Germany.
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Gene Transfer for Heart Failure Shows PromiseIntracoronary gene transfer among heart failure patients increased left ventricular function beyond standard heart failure therapy.
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Delays With Payers Mean Some Patients Miss Window for CAR T-Cell Therapy, Findings ShowAjeet Gajra, MD, MBBS, FACP, talks about identifying and removing the barriers for offering CAR T-cell therapy at the community practice level.
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DMD Trial Results Demonstrate Decrease in Creatine Kinase LevelsResults of a Phase 1/2a gene therapy clinical trial in children with Duchenne muscular dystrophy (DMD) revealed a significant decrease in levels of serum creatine kinase, an enzyme biomarker associated with muscle damage caused by DMD.
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Ophthalmology Overview: Gene Therapy Partially Restores Vision in Blind Patient, Presbyopia Therapy, and MoreHighlighting the latest ophthalmology-related news reported across MJH Life Sciences™.
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Scaling the Cell and Gene Therapy Supply Chain for GrowthWhile the cell and gene therapies approved so far are indicated for rare diseases with small patient populations, the successes of chimeric antigen receptor-T (CAR-T) therapies and expanding interest from biopharma stress the need to rapidly scale the supply chain as these therapies move toward commercial availability for more disease states and larger patient populations.
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Selective Inhibitor of FLT3 Allows High-Risk AML Patients to Bridge to Stem Cell TransplantA unique targeted therapy, quizartinib, was able to clear leukemia cells from the bone marrow in more than 33% of patients with an aggressive form of acute myeloid leukemia marked by a mutation in the FLT3 gene.
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Real-World Economic Value of a 21-Gene Assay in Early-Stage Breast CancerUniversal gene expression profiling of patients with stage II breast cancer resulted in outpatient savings of $11,000 (inclusive of testing costs) within 6 months of initiation of medical therapy.
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Real-World Economic Value of a 21-Gene Assay in Early-Stage Breast CancerUniversal gene expression profiling of patients with stage II breast cancer resulted in outpatient savings of $11,000 (inclusive of testing costs) within 6 months of initiation of medical therapy.
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Real-World Economic Value of a 21-Gene Assay in Early-Stage Breast CancerUniversal gene expression profiling of patients with stage II breast cancer resulted in outpatient savings of $11,000 (inclusive of testing costs) within 6 months of initiation of medical therapy.
Latest:
Real-World Economic Value of a 21-Gene Assay in Early-Stage Breast CancerUniversal gene expression profiling of patients with stage II breast cancer resulted in outpatient savings of $11,000 (inclusive of testing costs) within 6 months of initiation of medical therapy.
Latest:
Real-World Economic Value of a 21-Gene Assay in Early-Stage Breast CancerUniversal gene expression profiling of patients with stage II breast cancer resulted in outpatient savings of $11,000 (inclusive of testing costs) within 6 months of initiation of medical therapy.
Latest:
Real-World Economic Value of a 21-Gene Assay in Early-Stage Breast CancerUniversal gene expression profiling of patients with stage II breast cancer resulted in outpatient savings of $11,000 (inclusive of testing costs) within 6 months of initiation of medical therapy.
Latest:
Real-World Economic Value of a 21-Gene Assay in Early-Stage Breast CancerUniversal gene expression profiling of patients with stage II breast cancer resulted in outpatient savings of $11,000 (inclusive of testing costs) within 6 months of initiation of medical therapy.
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Humility and Hope: Evolution of the HIV Pandemic, From ART to Today's Cancer CuresThe connections between cancer and HIV/AIDS became clear relatively early in the HIV/AIDS pandemic and continue to this day. Not only were opportunistic infections present in a majority of HIV-infected patients who met the initial diagnostic criteria for AIDS, but several cancer types were far more prevalent as well. While there is still much to understand before HIV is fully conquered, we have already learned a great deal about the pathobiology of this virus that has helped advanced immune-oncological technologies and led to the development of increasingly effective gene therapy delivery systems.
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Robert Califf, MD, Nominated for FDA CommissionerThe professor of medicine at Duke University School of Medicine previously served as commissioner in 2016.
